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Chakraborty, Shalini and Roy, Sonti and Mistry, Hiral Uday and Murthy, Shweta and George, Neena and Bhandari, Vasundhra and Sharma, Paresh (2017) Potential Sabotage of Host Cell Physiology by Apicomplexan Parasites for Their Survival Benefits. Frontiers in Immunology, 8. ISSN 1664-3224


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Plasmodium, Toxoplasma, Cryptosporidium, Babesia, and Theileria are the major apicomplexan parasites affecting humans or animals worldwide. These pathogens represent an excellent example of host manipulators who can overturn host signaling pathways for their survival. They infect different types of host cells and take charge of the host machinery to gain nutrients and prevent itself from host attack. The mechanisms by which these pathogens modulate the host signaling pathways are well studied for Plasmodium, Toxoplasma, Cryptosporidium, and Theileria, except for limited studies on Babesia. Theileria is a unique pathogen taking into account the way it modulates host cell transformation, resulting in its clonal expansion. These parasites majorly modulate similar host signaling pathways, however, the disease outcome and effect is different among them. In this review, we discuss the approaches of these apicomplexan to manipulate the host–parasite clearance pathways during infection, invasion, survival, and egress.

Item Type: Article
Subjects: Animal Genetics and Genomics
Depositing User: Mr Harjit Singh
Date Deposited: 22 Nov 2018 06:45
Last Modified: 24 Apr 2019 05:57
URI: http://niab.sciencecentral.in/id/eprint/40

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