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Reddy, R. V. C. and Subramanian, B. M. and Surendra, K. S. N. L. (2014) Rabies virus isolates of India - Simultaneous existence of two distinct evolutionary lineages. Infection Genetics and Evolution, 27. pp. 163-172.

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Rabies is a fatal viral disease of serious public health implication. The disease is enzootic in India. In the present study, thirty six rabies virus isolates were obtained from terrestrial mammals of India during 2002-2012. Ecto-domain coding region of the glycoprotein gene from all the isolates were sequenced and the phylogenetic analysis was performed in relation to the global rabies and rabies related virus isolates. The Indian isolates grouped into two distinctly separate lineages with majority of the Indian isolates in Arctic like 1 lineage and the remaining isolates in sub-continental lineage. Isolates of the two distinct lineages were identified simultaneously from the same geographical region. Time scaled phylogenetic tree indicated that the sub-continental lineage of the virus is one of the earliest clade of rabies virus that diverged from bat rabies virus. On the contrary, the Arctic-like 1 lineage of India appeared to be a more recent divergence event. The amino acid sequence comparison revealed that all the major antigenic sites were almost conserved among the Indian isolates whereas few amino acid variations could be identified around site Ha, minor site I and IV. The d(N)/d(S) study based on G ecto-domain is in support of the earlier reports of strong purifying selection. In conclusion, it is evident that the Indian rabies virus isolates are of two major distinct lineages with distant phylogenetic and evolutionary relationship. (C) 2014 Elsevier B.V. All rights reserved.

Item Type: Article
Subjects: Animal Genetics and Genomics
Depositing User: Unnamed user with email alok@urdip.res.in
Date Deposited: 18 Mar 2015 06:13
Last Modified: 18 Mar 2015 06:13
URI: http://niab.sciencecentral.in/id/eprint/5

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