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Saqib, Uzma and Faisal, Syed M. and Saluja, Rohit and Baig, Mirza S. (2018) Structural insights of resveratrol with its binding partners in the toll-like receptor 4 pathway. Journal of Cellular Biochemistry, 120 (1). pp. 452-460. ISSN 07302312


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The benefits associated with resveratrol (Resv; 3,4',5-trihydroxy-trans-stilbene) are known for a long time. The therapeutic properties of Resv are observed in diseases like cancer, neurological disorders, atherosclerosis, aging, inflammation, etc. Multiple studies suggest that the beneficial properties of Resv are due to its binding to targets in multiple pathways. The same has been reflected in inflammation, where Resv has been shown to inhibit nuclear factor κ light-chain enhancer of activated B cells in the toll-like receptor 4 (TLR4) pathway. There are multiple cellular targets which bind to Resv, however the mode and the key interactions involved remain elusive for many of them. In the current work, we have investigated the structural insights of Resv with three of its binding partners involved in the inflammatory TLR4 signaling pathway. Through a structure-based modelling and molecular dynamics study, we have unraveled the molecular and atomic interactions involved in the Resv-binary complexes of inhibitor of κB kinase, cyclooxygeanse-2, and tank-binding kinase I, all three of which are key players in TLR4 inflammatory signaling. This study is the latest addition to the investigations of the structural partners of Resv and its molecular interactions..

Item Type: Article
Subjects: Animal Genetics and Genomics
Depositing User: Mr Harjit Singh
Date Deposited: 22 Nov 2018 10:46
Last Modified: 24 Apr 2019 05:59
URI: http://niab.sciencecentral.in/id/eprint/56

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