Brahma, Umarani and Kothari, Richa and Sharma, Paresh and Bhandari, Vasundhra (2018) Antimicrobial and anti-biofilm activity of hexadentated macrocyclic complex of copper (II) derived from thiosemicarbazide against Staphylococcus aureus. Scientific Reports, 8 (1). ISSN 2045-2322

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Abstract

Antimicrobial resistance (AMR) has emerged as a global threat to public health and have become the leading cause of mortality. Staphylococcus aureus is one of the primary cause of nosocomial infections associated with increased morbidity1,2 . Methicillin-resistant S. aureus (MRSA) is solely responsible for many life-threatening nosocomial infections in humans which increases the treatment duration and medical costs3,4 . Tey are also known to cause several mild to chronic infection in animals. Resistance against the last resort of drugs such as vancomycin and linezolid have emerged in the clinical isolates of S. aureus which have further worsened the scenario5,6 . Further, the problem of resistance is impended by the ability of S. aureus to form bioflms on biotic and abiotic surfaces especially on several medical implanted devices7–9 . Bioflm forming S. aureus is even more signifcant threat due to increased tolerance against antimicrobials and the host defence system3,9 . Bioflms are challenging to treat and considered as a bacterial reservoir for dissemination to various body sites8,10. Tese infections may result in the replacement of the implanted medical device, thereby causing increased distress with additional medical costs to the patient10–12. With the increasing mortality rate due to AMR, there is an urgent need to look for new strategies to develop antibiotics to fght multidrug-resistant and bioflms related infections13. Researchers are using various approaches to identify new antibiotics or new compounds with antimicrobial activity. Various inhibitors of diferent pathways, antimicrobial peptides derived from diferent ecosystems, and organic and inorganic synthetic compounds with antimicrobial activity have been identifed and studied14–22. In quest of fnding new compounds with antimicrobial activity along with the scarcity of new antibiotics in the pipeline, have drawn the focus towards development of Copper (Cu) complexes as antimicrobial18–2

Item Type:	Article
Subjects:	Animal Genetics and Genomics Infectious Diseases Inflammation Biology Reproductive Biology Genetic Engineering Bioinformatics
Depositing User:	Mr Harjit Singh
Date Deposited:	26 Jun 2019 08:27
Last Modified:	26 Jun 2019 11:09
URI:	http://niab.sciencecentral.in/id/eprint/61

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