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Vennila, Kailasam N. and Prabha, Kolandhaivel and Sunny, Deval and Madhuri, Subbiah and Elango, Kuppannagounder P. (2019) Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular docking. Medicinal Chemistry Research, 28 (8). pp. 1298-1307. ISSN 1054-2523

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A series of 2-chloro N-substituted amino quinolines (2a–2j) were prepared and characterized by analytical and spectroscopic methods. As quinoline is an important pharmacophoric moiety, the prepared compounds were screened against a non-small cell lung cancer cell line, A549. One of the compounds, 2-chloro-8-methyl-N-(quinolin-5-yl)quinolin-4-amine (2b) is found to be active with inhibition concentration value of (IC50) 29.4 μM. The molecular docking studies with the predominant PI3K/AKT/mTOR pathway proteins also revealed the lesser binding energy with 2b. All the compounds are predicted to satisfy the ADME profile and the results let us to consider 2b as a lead compound for new generation of A549 cell line inhibitors and for further studies in this way.

Item Type: Article
Subjects: Animal Genetics and Genomics
Infectious Diseases
Inflammation Biology
Reproductive Biology
Genetic Engineering
Depositing User: Mr Harjit Singh
Date Deposited: 26 Jun 2019 09:08
Last Modified: 26 Jun 2019 11:09
URI: http://niab.sciencecentral.in/id/eprint/71

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