Azam, Sarwar and Rao, Sashi Bhushan and Jakka, Padmaja and NarasimhaRao, Veera and Bhargavi, Bindu and Gupta, Vivek Kumar and Radhakrishnan, Girish (2016) Genetic Characterization and Comparative Genome Analysis ofBrucella melitensisIsolates from India. International Journal of Genomics, 2016. pp. 1-13. ISSN 2314-436X

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Abstract

Brucellosis is the most frequent zoonotic disease worldwide, with over 500,000 new human infections every year. Brucella melitensis, the most virulent species in humans, primarily affects goats and the zoonotic transmission occurs by ingestion of unpasteurized milk products or through direct contact with fetal tissues. Brucellosis is endemic in India but no information is available on population structure and genetic diversity of Brucella spp. in India. We performed multilocus sequence typing of four B. melitensis strains isolated from naturally infected goats from India. For more detailed genetic characterization, we carried out whole genome sequencing and comparative genome analysis of one of the B. melitensis isolates, Bm IND1. Genome analysis identified 141 unique SNPs, 78 VNTRs, 51 Indels, and 2 putative prophage integrations in the Bm IND1 genome. Our data may help to develop improved epidemiological typing tools and efficient preventive strategies to control brucellosis.

Item Type:	Article
Subjects:	Animal Genetics and Genomics
Depositing User:	Mr Harjit Singh
Date Deposited:	20 Nov 2018 09:29
Last Modified:	24 Apr 2019 05:08
URI:	http://niab.sciencecentral.in/id/eprint/24

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