Selvakumar, Balaraman and Gujjar, Naveen and Subbiah, Madhuri and Elango, Kuppanagounder P. (2018) Synthesis and antiviral study of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl) morpholine derivatives. Medicinal Chemistry Research, 27 (2). pp. 512-519. ISSN 1054-2523

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Abstract

A series of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl)morpholine substituted sulfonamide and urea derivatives has been synthesized and characterized using spectral techniques. The antiviral activity of these compounds against an avian paramyxo virus (AMPV-1) was screened using MTT assay and found that one of the sulfonamide derivatives (2d) show three-fold higher antiviral activity than Ribavirin, a commercial antiviral drug substance. Graphical abstract Open image in new window

Item Type:	Article
Subjects:	Animal Genetics and Genomics
Depositing User:	Mr Harjit Singh
Date Deposited:	22 Nov 2018 06:41
Last Modified:	24 Apr 2019 05:11
URI:	http://niab.sciencecentral.in/id/eprint/38

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